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Broccoli and Cancer

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The development of cancer in the human body is a long-term event that begins at the cellular level with an abnormality that typically only ten to twenty years later is diagnosed as cancer. While research continues at a furious pace to find ways to cure this deadly killer—after heart disease the greatest killer of Americans—most scientists have come to recognize that cancer might well be more easily prevented than cured.

Diet is the best tool we all have at hand to protect ourselves from developing cancer. We know that a typical Western diet plays a major role in the development of cancers and we know that at least 30 percent of all cancers are believed to have a dietary component. Population studies first pointed to the role that broccoli and other cruciferous vegetables might play in cancer prevention. One ten-year study, published by the Harvard School of Public Health, of 47,909 men showed an inverse relationship between the consumption of cruciferous vegetables and the development of bladder cancer. Broccoli and cabbage seemed to provide the greatest protection. Countless studies have confirmed these findings. As long ago as 1982, the National Research Council on Diet, Nutrition, and Cancer found “there is sufficient epidemiological evidence to suggest that consumption of cruciferous vegetables is associated with a reduction in cancer.”

A very recent meta-analysis, which reviewed the results of eighty seven case-controlled studies, confirmed once again that broccoli and other cruciferous vegetables lower the risk of cancer. As little 10 grams a day of crucifers (less than 1/8 cup of chopped raw cabbage or chopped raw broccoli) can have a significant effect on your risk for developing cancer. Indeed, eating broccoli or its sidekicks is like getting a natural dose of chemoprevention. One study showed that eating about two servings a day of crucifers may result in as much as a 50 percent reduction in the risk for certain types of cancers. While all crucifers seem to be effective in fighting cancer, cabbage, broccoli, and Brussels sprouts seem to be the most powerful. Just 1/2 cup of broccoli a day protects from a number of cancers, particularly cancers of the lung, stomach, colon, and rectum. No wonder broccoli is number one on the National Cancer Institute’s list of nutrition all-stars.

Broccoli is the vegetable with the strongest inverse association with colon cancer, especially in those younger than 65 with a history of smoking. If you’ve ever smoked, eat your broccoli!

The sulfur compounds in cruciferous vegetables are a major reason these foods are such powerful chemopreventive foods. The strong smell that broccoli, cabbage, and other cruciferous vegetables share comes from the sulfur compounds that protect the plant as well as you. The strong, sometimes bitter taste and smell of these vegetables protect them from insects and animals.

The particular compounds in broccoli that are so effective against cancer include the phytochemicals, sulforaphane, and the indoles. Sulforaphane is a remarkably potent compound that fights cancer on various fronts. It increases the enzymes that help rid the body of carcinogens, it actually kills abnormal cells, and it helps the body limit oxidation—the process that initiates many chronic diseases—at the cellular level. Indoles work to combat cancer through their effect on estrogen. They block estrogen receptors in breast cancer cells, inhibiting the growth of estrogen-sensitive breast cancers. The most important indole in broccoli—indole-3-carbinol, or I3C—is thought to be an especially effective breast cancer preventive agent. In a study at the Institute for Hormone Research, in New York, sixty women were divided into groups, some eating a high I3C diet containing 400 milligrams of I3C daily, another eating a high-fiber diet, and yet a third control group on a placebo diet. The women consuming the high I3C diet showed significantly higher levels of a cancer-preventive form of estrogen. The other diets showed no increase in this substance.
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